José M Lassaletta (Instituto de Investigaciones Químicas (CSIC-US), Spain)
Readership: Advanced undergraduate and graduate students in chemistry chemists interested in asymmetric catalysis, organocatalysis, organic synthesis.
Chapter contribution from Ben Feringa, Nobel Laureate in Chemistry 2016.
Atropisomerism and Axial Chirality provides a global survey of the chemistry of axially chiral compounds including biaryls, heterobiaryls, non-biaryl atropisomers, allenes and spyrocyclic derivatives. From the perspective of a synthetic organic chemist, this book provides a unique compilation of the available methodologies for their synthesis, with emphasis on the most efficient and modern strategies, a review of the huge amount of practical applications in the field of asymmetric catalysis, either as transition metal ligands or as organocatalysts, and an overview of their occurrence as bioactive compounds and natural products.
The first of its kind, this book serves as a general introduction and a practical reference to advanced chemistry students and researchers, while also offering creative ideas for further developments in the field.
About the Editor
Asymmetric Synthesis of Axially Chiral Biaryls and Heterobiaryls (Abel Ros, Pedro Ramírez-López, Rosario Fernández, and José María Lassaletta)
Applications of Axially Chiral Organocatalysts (Azusa Kondoh and Masahiro Terada)
Axially chiral P,P-Ligands for Asymmetric Metal-Catalyzed Reactions (Taiga Yurino and Takeshi Ohkuma)
Axially Chiral Monodentate Phosphorus Ligands for Asymmetric Metal-Catalysed Reactions (Jean-Baptiste Gualtierotti, Valentín Hornillos, and Ben L Feringa)
Axially Chiral P,X-Ligands (X=N, O, and S) for Asymmetric Metal-Catalyzed Reactions (Balaji V Rokade and Patrick J Guiry)
Axially Chiral X,X-Ligands (X=N, O) for Asymmetric Metal-Catalyzed Reactions (Jun Ying and Lin Pu)
Non-Biaryl Atropisomers: Anilides, Amides, Lactams, and Analogues with C–C and C–X Stereogenic Axes (Ramya Raghunathan, Elango Kumarasamy, Jayaraman Sivaguru, and Mukund P Sibi)
Axial Chirality Beyond Atropisomerism: Allenes and Related Compounds (Benito Alcaide, Pedro Almendros, and Cristina Aragoncillo)
Axially Chiral Natural Products and Bioactive Compounds (Paul A Keller, Nicholas M Butler, and Patrick M McCosker)