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Artificial Intelligence in Drug Discovery-Editor: Nathan Brown
  • 2020-12-16
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    ###-Book Description Begin-###
    -------如果这里没有任何信息,不是真没有,是我们懒!请复制书名上amazon搜索书籍信息。-------

    Artificial Intelligence in Drug Discovery-Editor: Nathan Brown

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    Publication details

    https://doi.org/10.1039/9781788016841


    Print publication date

    12 Nov 2020

    Copyright year

    2021

    Print ISBN

    978-1-78801-547-9

    PDF eISBN

    978-1-78801-684-1

    ePub eISBN

    978-1-83916-054-7


    About this book

    Following significant advances in deep learning and related areas interest in artificial intelligence (AI) has rapidly grown. In particular, the application of AI in drug discovery provides an opportunity to tackle challenges that previously have been difficult to solve, such as predicting properties, designing molecules and optimising synthetic routes. Artificial Intelligence in Drug Discovery aims to introduce the reader to AI and machine learning tools and techniques, and to outline specific challenges including designing new molecular structures, synthesis planning and simulation. Providing a wealth of information from leading experts in the field this book is ideal for students, postgraduates and established researchers in both industry and academia.

     Preliminary content


    Front Matter

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    Pages 1 - 6


    Preface

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    Pages 7 - 8


    Contents

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    Pages 9 - 17

    Chapter 1

    Introduction

    Nathan Brown

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    Pages 1 - 6

    Chapter 2

    The History of Artificial Intelligence and Chemistry

    Nathan Brown

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    Pages 7 - 14

    Chapter 3

    Chemical Topic Modeling – An Unsupervised Approach Originating from Text-mining to Organize Chemical Data

    Nadine Schneider, Nikolas Fechner, Nikolaus Stiefl and Gregory A. Landrum

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    Pages 15 - 44

    Chapter 4

    Deep Learning and Chemical Data

    Colin Batchelor, Peter Corbett, Aileen Day, Jeff White and John Boyle

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    Pages 45 - 62

    Chapter 5

    Concepts and Applications of Conformal Prediction in Computational Drug Discovery

    Isidro Cortés-Ciriano and Andreas Bender

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    Pages 63 - 101

    Chapter 6

    Non-applicability Domain. The Benefits of Defining “I Don't Know” in Artificial Intelligence

    Damjan Krstajic

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    Pages 102 - 118

    Chapter 7

    Predicting Protein-ligand Binding Affinities

    José Jiménez-Luna and Gianni De Fabritiis

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    Pages 119 - 150

    Chapter 8

    Virtual Screening with Convolutional Neural Networks

    Fergus Imrie, Anthony R. Bradley and Charlotte M. Deane

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    Pages 151 - 183

    Chapter 9

    Machine Learning in the Area of Molecular Dynamics Simulations

    Shuzhe Wang and Sereina Riniker

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    Pages 184 - 214

    Chapter 10

    Compound Design Using Generative Neural Networks

    T. Blaschke and J. Bajorath

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    Pages 215 - 227

    Chapter 11

    Junction Tree Variational Autoencoder for Molecular Graph Generation

    Wengong Jin, Regina Barzilay and Tommi Jaakkola

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    Pages 228 - 249

    Chapter 12

    AI via Matched Molecular Pair Analysis

    Ed Griffen, Alexander Dossetter and Andrew G. Leach

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    Pages 250 - 271

    Chapter 13

    Molecular De Novo Design Through Deep Generative Models

    Ola Engkvist, Josep Arús-Pous, Esben Jannik Bjerrum and Hongming Chen

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    Pages 272 - 300

    Chapter 14

    Active Learning for Drug Discovery and Automated Data Curation

    D. Reker

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    Pages 301 - 326

    Chapter 15

    Data-driven Prediction of Organic Reaction Outcomes

    Connor W. Coley

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    Pages 327 - 348

    Chapter 16

    ChemOS: An Orchestration Software to Democratize Autonomous Discovery

    Loïc M. Roch, Florian Häse and Alán Aspuru-Guzik

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    Pages 349 - 388

    Chapter 17

    Summary and Outlook

    Nathan Brown

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    Pages 389 - 393

    Subject Index

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    Pages 394 - 405



    ###-Book Description End-###
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